文章基本信息

标题：Association of H.pylori cagA Gene with Duodenal Ulcer & Gastric Carcinoma in Bangladeshi Patients
本地全文：下载
作者：Ritu Saha ; Sharmeen Ahmed ; Humayun Sattar 等
期刊名称：American Journal of Microbiological Research
印刷版ISSN：2328-4129
电子版ISSN：2328-4137
出版年度：2018
卷号：6
期号：2
页码：57-62
DOI：10.12691/ajmr-6-2-4
出版社：Science and Education Publishing
摘要：Background: Prolong infection with Helicobacter pylori may lead to chronic inflammation of gastroduodenal mucosa which in turns develops into severe diseases like peptic ulcer and gastric carcinoma. Bacterial virulence factor Cytotoxin Associated gene (cagA) is found to be responsible for developing such severe diseases in different countries. So this study was conducted to assess the relationship between occurrence of several gastroduodenal diseases and the presence of H. pylori cagA gene in Bangladeshi patients. Methods: Endoscopic gastroduodenal biopsy sample of 113 dyspeptic patients from different districts of Bangladesh were studied. H. pylori infection was detected by Rapid urease test, PCR of ureC gene and histological staining (Geimsa). Gastroduodenal disease was diagnosed by histopathological examination and cagA gene was detected by PCR. Result: H. pylori infection was identified among 48% (54/113) patients. Fifty seven percent of H. pylori infected patients were found to be cagA gene positive. cagA gene is significantly associated with Duodenal ulcer (p= .024) and Gastric carcimoma (p < .001). However, a further larger study is required to confirm this finding.
关键词：H. pylori infection; cagA gene; duodenal ulcer; gastric carcinoma