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标题：Metabolism and proteomics of large and small dense LDL in combined hyperlipidemia: effects of rosuvastatin
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作者：Nuntakorn Thongtang ; Margaret R. Diffenderfer ; Esther M. M. Ooi 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2017
卷号：58
期号：7
页码：1315-1324
DOI：10.1194/jlr.M073882
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Small dense LDL (sdLDL) has been reported to be more atherogenic than large buoyant LDL (lbLDL). We examined the metabolism and protein composition of sdLDL and lbLDL in six subjects with combined hyperlipidemia on placebo and rosuvastatin 40 mg/day. ApoB-100 kinetics in triglyceride-rich lipoproteins (TRLs), lbLDL (density [ d ] = 1.019–1.044 g/ml), and sdLDL ( d = 1.044–1.063 g/ml) were determined in the fed state by using stable isotope tracers, mass spectrometry, and compartmental modeling. Compared with placebo, rosuvastatin decreased LDL cholesterol and apoB-100 levels in TRL, lbLDL, and sdLDL by significantly increasing the fractional catabolic rate of apoB-100 (TRL, +45%; lbLDL, +131%; and sdLDL, +97%), without a change in production. On placebo, 25% of TRL apoB-100 was catabolized directly, 37% was converted to lbLDL, and 38% went directly to sdLDL; rosuvastatin did not alter these distributions. During both phases, sdLDL apoB-100 was catabolized more slowly than lbLDL apoB-100 ( P P
关键词：lipoproteins/kinetics ; LDL subfractions ; statins ; dyslipidemia ; atherosclerosis ; mass spectrometry ; mathematical modeling