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标题：Nicotinic acid timed to feeding reverses tissue lipid accumulation and improves glucose control in obese Zucker rats[S]
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作者：Tobias Kroon ; Tania Baccega ; Arne Olsén 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2017
卷号：58
期号：1
页码：31-41
DOI：10.1194/jlr.M068395
语种：English
出版社：American Society for Biochemistry and Molecular Biology
摘要：Nicotinic acid (NiAc) is a potent inhibitor of lipolysis, acutely reducing plasma free fatty acid (FFA) concentrations. However, a major FFA rebound is seen during rapid NiAc washout, and sustained exposure is associated with tolerance development, with FFAs returning to pretreatment levels. Our aim was to find a rational NiAc dosing regimen that preserves FFA lowering, sufficient to reverse nonadipose tissue lipid accumulation and improve metabolic control, in obese Zucker rats. We compared feeding-period versus fasting-period NiAc dosing for 5 days: 12 h subcutaneous infusion (programmable, implantable mini-pumps) terminated by gradual withdrawal. It was found that NiAc timed to feeding decreased triglycerides in liver (−47%; P P
关键词：lipolysis and fatty acid metabolism ; diabetes ; insulin ; adipose tissue ; drug therapy/hypolipidemic drugs ; niacin ; GPR109A ; liver