出版社：American Society for Biochemistry and Molecular Biology
摘要：We aimed to determine the risk factors associated with the depletion of large HDL particles and enrichment of small HDL particles observed in adolescents with T2D. Four groups of adolescents were recruited: 1 ) lean insulin-sensitive (L-IS), normal BMI and no insulin resistance; 2 ) lean insulin-resistant (L-IR), normal BMI but insulin resistance (fasting insulin levels ≥ 25 mU/ml and homeostatic model assessment of insulin resistance ≥ 6); 3 ) obese insulin-sensitive (O-IS), BMI ≥ 95th percentile and no insulin resistance; and 4 ) obese insulin-resistant (O-IR), BMI ≥ 95th percentile and insulin resistance. Plasma was separated by using gel-filtration chromatography to assess the HDL subspecies profile and compared with that of obese adolescents with T2D (O-T2D). Large HDL subspecies were significantly lower across groups from L-IS > L-IR > O-IS > O-IR > O-T2D ( P P
关键词：high density lipoprotein ; insulin resistance ; diabetes ; phospholipids
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