文章基本信息

标题：Genetic Modulation of Training and Transfer in Older Adults: BDNF Val66Met Polymorphism is Associated with Wider Useful Field of View
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作者：Colzato, Lorenza S ; van Muijden, Jesse ; Band, Guido P H 等
期刊名称：Frontiers in Psychology
电子版ISSN：1664-1078
出版年度：2011
卷号：2
页码：1-6
DOI：10.3389/fpsyg.2011.00199
出版社：Frontiers Media
摘要：Western society has an increasing proportion of older adults. Increasing age is associated with a general decrease in the control over task-relevant mental processes. In the present study we investigated the possibility that successful transfer of game-based cognitive improvements to untrained tasks in elderly people is modulated by preexisting neuro-developmental factors as genetic variability related to levels of the brain-derived neurotrophic factor (BDNF), an important neuromodulator underlying cognitive processes. We trained participants, genotyped for the BDNF Val66Met polymorphism, on cognitive tasks developed to improve dynamic attention. Pre-training (baseline) and post-training measures of attentional processes (divided and selective attention) were acquired by means of the Useful Field of View (UFOV) task. As expected, Val/Val homozygous individuals showed larger beneficial transfer effects than Met/-carriers. Our findings support the idea that genetic predisposition modulates transfer effects.
关键词：Brain-derived neurotrophic factor (BDNF); Useful Field of View (UFOV); videogame