文章基本信息

标题：Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring
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作者：Taku James Sairenji ; Jun Ikezawa ; Ryosuke Kaneko 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2017
卷号：114
期号：49
页码：13042-13047
DOI：10.1073/pnas.1621196114
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Although maternal nurturing behavior is extremely important for the preservation of a species, our knowledge of the biological underpinnings of these behaviors is insufficient. Here we show that the degree of a mother’s nurturing behavior is regulated by factors present during her own fetal development. We found that Cin85-deficient ( Cin85 ^−/−) mother mice had reduced pituitary hormone prolactin (PRL) secretion as a result of excessive dopamine signaling in the brain. Their offspring matured normally and produced their own pups; however, nurturing behaviors such as pup retrieval and nursing were strongly inhibited. Surprisingly, when WT embryos were transplanted into the fallopian tubes of Cin85 ^−/− mice, they also exhibited inhibited nurturing behavior as adults. Conversely, when Cin85 ^−/− embryos were transplanted into the fallopian tubes of WT mice, the resultant pups exhibited normal nurturing behaviors as adults. When PRL was administered to Cin85 ^−/− mice during late pregnancy, a higher proportion of the resultant pups exhibited nurturing behaviors as adults. This correlates with our findings that neural circuitry associated with nurturing behaviors was less active in pups born to Cin85 ^−/− mothers, but PRL administration to mothers restored neural activity to normal levels. These results suggest that the prenatal period is extremely important in determining the expression of nurturing behaviors in the subsequent generation, and that maternal PRL is one of the critical factors for expression. In conclusion, perinatally secreted maternal PRL affects the expression of nurturing behaviors not only in a mother, but also in her pups when they have reached adulthood.
关键词：nurturing behavior ; neglect ; prenatal environment ; prolactin ; fetal brain