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标题：Effect of High Methionine and Folic Acid Diet on the Level of Homocysteine and Lipid Profile in Experimental Rats
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作者：Renata Bieżanowska-Kopeć ; Teresa Leszczyńska
期刊名称：Polish Journal of Food and Nutrition Sciences
印刷版ISSN：1230-0322
电子版ISSN：2083-6007
出版年度：2017
卷号：67
期号：3
页码：219-224
DOI：10.1515/pjfns-2016-0027
语种：English
出版社：Walter de Gruyter GmbH
摘要：The aim of this study was to reduce the level of homocysteine (Hcy) by high-methionine dietary supplementation of folic acid and to evaluate changes in lipid parameters in blood serum of experimental rats. The animals were randomly divided into seven groups (n=6, male), and were fed seven different diets for 52 days. The rodents were fed with the AIN-93G semi-synthetic diet (group I), supplemented with 32 g of methionine/kg diet (group II), whereas groups III-VII were fed with AIN-93G semi-synthetic diet supplemented with 32 g of methionine/kg diet and 2, 4, 8, 18 and 28 g of folic acid/kg diet, respectively. Contents of of homocysteine, total cholesterol level, HDL fraction and triacylglycerols were assessed enzymatically in rats serum. In addition, the LDL+VLDL cholesterol content was calculated. Folic acid content in the diet was found to be highly negatively correlated with homocysteine content (r=-0.95) and negatively correlated with triacylglycerols content (r=−0.94) in the serum of rats. In the serum of rats which were fed the methionine diet with the highest-folic acid supplementation (28 mg folic acid/kg diet), homocysteine and triglyceride contents were significantly lower, compared to animals fed other types of experimental diets.
关键词：methionine ; folic acid ; homocysteine ; lipid profile ; rats