文章基本信息

标题：Synthesis of Fluorine-Containing 6-Arylpurine Derivatives via Cp*Co(III)-Catalyzed C–H Bond Activation
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作者：Nanami Murakami ; Misaki Yoshida ; Tatsuhiko Yoshino 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2018
卷号：66
期号：1
页码：51-54
DOI：10.1248/cpb.c17-00797
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：

Cp*Co(III)-catalyzed (Cp*=pentamethylcyclopentadienyl) C–H bond functionalization of 6-arylpurines using gem -difluoroalkenes and allyl fluorides is described. The reaction with gem -difluoroalkenes afforded monofluoroalkenes with high ( Z )-selectivity, while the reaction with allyl fluorides led to C–H allylation in moderate ( Z )-selectivity. Both reactions proceeded using a user-friendly single-component catalyst [Cp*Co(CH₃CN)₃](SbF₆)₂ in fluorinated alcohol solvents without any additives. Robustness was also demonstrated by a preparative-scale reaction under air.
关键词：C–H bond functionalization;6-arylpurine;cobalt catalysis;gem-difluoroalkene;allyl fluoride