文章基本信息

标题：Epigenetic Regulatory Mechanisms Induced by Resveratrol
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作者：Guilherme Felipe Santos Fernandes ; Gabriel Dalio Bernardes Silva ; Aline Renata Pavan 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2017
卷号：9
期号：11
页码：1201
DOI：10.3390/nu9111201
语种：English
出版社：MDPI Publishing
摘要：Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).
关键词：resveratrol; epigenetic targets; histone deacetylase; SIRT1; DNA methyltransferase; histone acetyltransferase resveratrol ; epigenetic targets ; histone deacetylase ; SIRT1 ; DNA methyltransferase ; histone acetyltransferase