文章基本信息

标题：The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
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作者：Mee-Sup Yoon
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2017
卷号：9
期号：11
页码：1176
DOI：10.3390/nu9111176
语种：English
出版社：MDPI Publishing
摘要：The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms two distinct multiprotein complexes known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which are characterized by the presence of raptor and rictor, respectively. mTOR controls insulin signaling by regulating several downstream components such as growth factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1), F-box/WD repeat-containing protein 8 (Fbw8), and insulin like growth factor 1 receptor/insulin receptor (IGF-IR/IR). In addition, mTORC1 and mTORC2 regulate each other through a feedback loop to control cell growth. This review outlines the current understanding of mTOR regulation in insulin signaling in the context of whole body metabolism.
关键词：insulin; mammalian target of rapamycin (mTOR); mTOR complex1 (mTORC1); mTOR complex2 (mTORC2); protein kinase B (PKB/Akt) insulin ; mammalian target of rapamycin (mTOR) ; mTOR complex1 (mTORC1) ; mTOR complex2 (mTORC2) ; protein kinase B (PKB/Akt)