文章基本信息

标题：Nutrimiromics: Role of microRNAs and Nutrition in Modulating Inflammation and Chronic Diseases
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作者：Bruna J. Quintanilha ; Bruna Z. Reis ; Graziela B. Silva Duarte 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2017
卷号：9
期号：11
页码：1168
DOI：10.3390/nu9111168
语种：English
出版社：MDPI Publishing
摘要：Nutrimiromics studies the influence of the diet on the modification of gene expression due to epigenetic processes related to microRNAs (miRNAs), which may affect the risk for the development of chronic diseases. miRNAs are a class of non-coding endogenous RNA molecules that are usually involved in post-transcriptional gene silencing by inducing mRNA degradation or translational repression by binding to a target messenger RNA. They can be controlled by environmental and dietary factors, particularly by isolated nutrients or bioactive compounds, indicating that diet manipulation may hold promise as a therapeutic approach in modulating the risk of chronic diseases. This review summarizes the evidence regarding the influence of nutrients and bioactive compounds on the expression of miRNAs related to inflammation and chronic disease in several models (cell culture, animal models, and human trials).
关键词：microRNA; nutrients; inflammation; epigenetic microRNA ; nutrients ; inflammation ; epigenetic