文章基本信息

标题：Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanisms and Therapy
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作者：Junli Ma ; Qihang Zhou ; Houkai Li 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2017
卷号：9
期号：10
页码：1124
DOI：10.3390/nu9101124
语种：English
出版社：MDPI Publishing
摘要：The gut microbiota plays critical roles in development of obese-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes(T2D), and insulin resistance(IR), highlighting the potential of gut microbiota-targeted therapies in these diseases. There are various ways that gut microbiota can be manipulated, including through use of probiotics, prebiotics, synbiotics, antibiotics, and some active components from herbal medicines. In this review, we review the main roles of gut microbiota in mediating the development of NAFLD, and the advances in gut microbiota-targeted therapies for NAFLD in both the experimental and clinical studies, as well as the conclusions on the prospect of gut microbiota-targeted therapies in the future.
关键词：gut microbiota; obesity; insulin resistance; NAFLD; probiotic; prebiotic; symbiotic gut microbiota ; obesity ; insulin resistance ; NAFLD ; probiotic ; prebiotic ; symbiotic