文章基本信息

标题：Vitamin D and Age-Related Macular Degeneration
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作者：Alfredo Garcia Layana ; Angelo Maria Minnella ; Gerhard Garhöfer 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2017
卷号：9
期号：10
页码：1120
DOI：10.3390/nu9101120
语种：English
出版社：MDPI Publishing
摘要：In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.
关键词：vitamin D; age-related macular degeneration; inflammation; angiogenesis vitamin D ; age-related macular degeneration ; inflammation ; angiogenesis