文章基本信息

标题：Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care
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作者：Junji Yodoi ; Yoshiyuki Matsuo ; Hai Tian 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2017
卷号：9
期号：10
页码：1081
DOI：10.3390/nu9101081
语种：English
出版社：MDPI Publishing
摘要：Human thioredoxin (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys-, which is induced by biological stress due to oxidative damage, metabolic dysfunction, chemicals, infection/inflammation, irradiation, or hypoxia/ischemia-reperfusion. Our research has demonstrated that exogenous TRX is effective in a wide variety of inflammatory diseases, including viral pneumonia, acute lung injury, gastric injury, and dermatitis, as well as in the prevention and amelioration of food allergies. Preclinical and clinical studies using recombinant TRX (rhTRX) are now underway. We have also identified substances that induce the expression of TRX in the body, in vegetables and other plant ingredients. Skincare products are being developed that take advantage of the anti-inflammatory and anti-allergic action of TRX. Furthermore, we are currently engaged in the highly efficient production of pure rhTRX in several plants, such as lettuce, grain and rice.
关键词：inflammation; oxidative stress; redox; thioredoxin; thioredoxin-interacting protein inflammation ; oxidative stress ; redox ; thioredoxin ; thioredoxin-interacting protein