文章基本信息

标题：Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress
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作者：Jorge G. Farías ; Víctor M. Molina ; Rodrigo A. Carrasco 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2017
卷号：9
期号：9
页码：966
DOI：10.3390/nu9090966
语种：English
出版社：MDPI Publishing
摘要：Oxidative stress (OS) refers to the imbalance between the generation of reactive oxygen species (ROS) and the ability to scavenge these ROS by endogenous antioxidant systems, where ROS overwhelms the antioxidant capacity. Excessive presence of ROS results in irreversible damage to cell membranes, DNA, and other cellular structures by oxidizing lipids, proteins, and nucleic acids. Oxidative stress plays a crucial role in the pathogenesis of cardiovascular diseases related to hypoxia, cardiotoxicity and ischemia–reperfusion. Here, we describe the participation of OS in the pathophysiology of cardiovascular conditions such as myocardial infarction, anthracycline cardiotoxicity and congenital heart disease. This review focuses on the different clinical events where redox factors and OS are related to cardiovascular pathophysiology, giving to support for novel pharmacological therapies such as omega 3 fatty acids, non-selective betablockers and microRNAs.
关键词：hypoxia; oxidative stress; cardiac tissue; microRNA; omega 3 fatty acids; carvedilol; congenital heart disease hypoxia ; oxidative stress ; cardiac tissue ; microRNA ; omega 3 fatty acids ; carvedilol ; congenital heart disease