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标题：Low Docosahexaenoic Acid, Dihomo-Gamma-Linolenic Acid, and Arachidonic Acid Levels Associated with Long-Term Mortality in Patients with Acute Decompensated Heart Failure in Different Nutritional Statuses
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作者：Shohei Ouchi ; Tetsuro Miyazaki ; Kazunori Shimada 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2017
卷号：9
期号：9
页码：956
DOI：10.3390/nu9090956
语种：English
出版社：MDPI Publishing
摘要：The clinical significance of polyunsaturated fatty acids (PUFAs) in acute decompensated heart failure (ADHF) in various nutritional statuses remains unclear. For this study, we enrolled 267 patients with ADHF admitted to the cardiac intensive care unit at Juntendo University hospital between April 2012 and March 2014. The association between long-term mortality, the geriatric nutritional risk index (GNRI), and levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), dihomo-gamma-linolenic acid (DGLA), and arachidonic acid (AA) was investigated. The median age was 73 (64–82) years, and mortality was 29% (62 patients). The event-free survival rates for all-cause death were higher in patients with high PUFA levels or GNRI than in those with low PUFA levels or GNRI (p < 0.05 for all). In particular, high DGLA in the low-GNRI group and high DHA or AA in the high-GNRI group were associated with high event-free survival (p < 0.05 for all). After accounting for confounding variables, DHA, DGLA, and AA, but not EPA, were associated with long-term mortality (p < 0.01 for all). This study concludes that in patients with ADHF, decreased levels of DHA, DGLA, and AA are independently associated with long-term mortality in the various nutritional statuses.
关键词：polyunsaturated fatty acids (PUFAs); eicosapentaenoic acid (EPA); docosahexaenoic acid (DHA); dihomo-gamma-linolenic acid (DGLA); arachidonic acid (AA); geriatric nutritional risk index (GNRI); acute decompensated heart failure (ADHF); nutritional status polyunsaturated fatty acids (PUFAs) ; eicosapentaenoic acid (EPA) ; docosahexaenoic acid (DHA) ; dihomo-gamma-linolenic acid (DGLA) ; arachidonic acid (AA) ; geriatric nutritional risk index (GNRI) ; acute decompensated heart failure (ADHF) ; nutritional status