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标题：Food-Derived Antioxidant Polysaccharides and Their Pharmacological Potential in Neurodegenerative Diseases
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作者：Haifeng Li ; Fei Ding ; Lingyun Xiao 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2017
卷号：9
期号：7
页码：778
DOI：10.3390/nu9070778
语种：English
出版社：MDPI Publishing
摘要：Oxidative stress is known to impair architecture and function of cells, which may lead to various chronic diseases, and therefore therapeutic and nutritional interventions to reduce oxidative damages represent a viable strategy in the amelioration of oxidative stress-related disorders, including neurodegenerative diseases. Over the past decade, a variety of natural polysaccharides from functional and medicinal foods have attracted great interest due to their antioxidant functions such as scavenging free radicals and reducing oxidative damages. Interestingly, these antioxidant polysaccharides are also found to attenuate neuronal damages and alleviate cognitive and motor decline in a range of neurodegenerative models. It has recently been established that the neuroprotective mechanisms of polysaccharides are related to oxidative stress-related pathways, including mitochondrial function, antioxidant defense system and pathogenic protein aggregation. Here, we first summarize the current status of antioxidant function of food-derived polysaccharides and then attempt to appraise their anti-neurodegeneration activities.
关键词：polysaccharide; antioxidant; oxidative stress; inflammatory stress; proteotoxic stress; neurodegeneration polysaccharide ; antioxidant ; oxidative stress ; inflammatory stress ; proteotoxic stress ; neurodegeneration