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标题：Impact of Novel Sorghum Bran Diets on DSS-Induced Colitis
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作者：Lauren E. Ritchie ; Stella S. Taddeo ; Brad R. Weeks 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2017
卷号：9
期号：4
页码：330
DOI：10.3390/nu9040330
语种：English
出版社：MDPI Publishing
摘要：We have demonstrated that polyphenol-rich sorghum bran diets alter fecal microbiota; however, little is known regarding their effect on colon inflammation. Our aim was to characterize the effect of sorghum bran diets on intestinal homeostasis during dextran sodium sulfate (DSS)-induced colitis. Male Sprague-Dawley rats (N = 20/diet) were provided diets containing 6% fiber from cellulose, or Black (3-deoxyanthocyanins), Sumac (condensed tannins) or Hi Tannin Black (both) sorghum bran. Colitis was induced (N = 10/diet) with three separate 48-h exposures to 3% DSS, and feces were collected. On Day 82, animals were euthanized and the colon resected. Only discrete mucosal lesions, with no diarrhea or bloody stools, were observed in DSS rats. Only bran diets upregulated proliferation and Tff3, Tgfβ and short chain fatty acids (SCFA) transporter expression after a DSS challenge. DSS did not significantly affect fecal SCFA concentrations. Bran diets alone upregulated repair mechanisms and SCFA transporter expression, which suggests these polyphenol-rich sorghum brans may suppress some consequences of colitis.
关键词：colon; gene expression; inflammatory bowel disease; dietary fiber; polyphenols; short chain fatty acids; Sorghum bicolor colon ; gene expression ; inflammatory bowel disease ; dietary fiber ; polyphenols ; short chain fatty acids ; Sorghum bicolor