文章基本信息

标题：Genetic Variations Associated with Vitamin A Status and Vitamin A Bioavailability
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作者：Patrick Borel ; Charles Desmarchelier
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2017
卷号：9
期号：3
页码：246
DOI：10.3390/nu9030246
语种：English
出版社：MDPI Publishing
摘要：Blood concentration of vitamin A (VA), which is present as different molecules, i.e., mainly retinol and provitamin A carotenoids, plus retinyl esters in the postprandial period after a VA-containing meal, is affected by numerous factors: dietary VA intake, VA absorption efficiency, efficiency of provitamin A carotenoid conversion to VA, VA tissue uptake, etc. Most of these factors are in turn modulated by genetic variations in genes encoding proteins involved in VA metabolism. Genome-wide association studies (GWAS) and candidate gene association studies have identified single nucleotide polymorphisms (SNPs) associated with blood concentrations of retinol and β-carotene, as well as with β-carotene bioavailability. These genetic variations likely explain, at least in part, interindividual variability in VA status and in VA bioavailability. However, much work remains to be done to identify all of the SNPs involved in VA status and bioavailability and to assess the possible involvement of other kinds of genetic variations, e.g., copy number variants and insertions/deletions, in these phenotypes. Yet, the potential usefulness of this area of research is exciting regarding the proposition of more personalized dietary recommendations in VA, particularly in populations at risk of VA deficiency.
关键词：genetic polymorphisms; absorption; bioavailability; β-carotene; retinyl palmitate; retinol; nutrigenetics; blood concentration; provitamin A; carotenoids; β-cryptoxanthin; α-carotene; postprandial genetic polymorphisms ; absorption ; bioavailability ; β-carotene ; retinyl palmitate ; retinol ; nutrigenetics ; blood concentration ; provitamin A ; carotenoids ; β-cryptoxanthin ; α-carotene ; postprandial