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标题：Changes in the Anti-Allergic Activities of Sesame by Bioconversion
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作者：Tae-Dong Jung ; Sun-Il Choi ; Seung-Hyun Choi 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2018
卷号：10
期号：2
页码：210
DOI：10.3390/nu10020210
语种：English
出版社：MDPI Publishing
摘要：Sesame is an important oilseed crop, which has been used as a traditional health food to ameliorate the prevention of various diseases. We evaluated the changes in the anti-allergic activities of sesame by bioconversion. SDS-PAGE of non-fermented sesame proteins showed major allergen bands, while that of fermented sesame showed only a few protein bands. Additionally, we investigated the effectiveness of fermented sesame by bioconversion in tumor necrosis factor-α (TNF-α)- and interferon-γ (IFN-γ)-induced HaCaT cells. In HaCaT cells, fermented sesame inhibited the mRNA expression of interleukin-6 (IL-6) and interleukin-1β (IL-1β), thymus and macrophage-derived chemokine (MDC/CCL22), activation-regulated chemokine (TARC/CCL17), and intercellular adhesion molecule-1 (ICAM-1). Moreover, fermented sesame inhibited the activation of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 1 (STAT1). Fermented sesame exerts anti-allergic effects by suppressing the expression of chemokines and cytokines via blockade of NF-κB and STAT1 activation.
关键词：atopic dermatitis; bioconversion; Sesamum indicum L.; skin inflammation; anti-allergic atopic dermatitis ; bioconversion ; Sesamum indicum L. ; skin inflammation ; anti-allergic