文章基本信息

标题：Batzella, Crambe and Monanchora: Highly Prolific Marine Sponge Genera Yielding Compounds with Potential Applications for Cancer and Other Therapeutic Areas
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作者：Amr El-Demerdash ; Atanas G. Atanasov ; Anupam Bishayee 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2018
卷号：10
期号：1
页码：33
DOI：10.3390/nu10010033
语种：English
出版社：MDPI Publishing
摘要：Pyrroloquinoline and guanidine-derived alkaloids present distinct groups of marine secondary metabolites with structural diversity that displayed potentialities in biological research. A considerable number of these molecular architectures had been recorded from marine sponges belonging to different marine genera, including Batzella, Crambe, Monanchora, Clathria, Ptilocaulis and New Caledonian starfishes Fromia monilis and Celerina heffernani. In this review, we aim to comprehensively cover the chemodiversity and the bioactivities landmarks centered around the chemical constituents exclusively isolated from these three marine genera including Batzella, Crambe and Monanchora over the period 1981–2017, paying a special attention to the polycyclic guanidinic compounds and their proposed biomimetic landmarks. It is concluded that these marine sponge genera represent a rich source of novel compounds with potential applications for cancer and other therapeutic areas.
关键词：marine sponges; Poecilosclerida; Batzella; Crambe ; Monanchora ; guanidine alkaloids; pyrroloquinoline alkaloids; bioactivities; biomimetic synthesis marine sponges ; Poecilosclerida ; Batzella ; Crambe ; Monanchora ; guanidine alkaloids ; pyrroloquinoline alkaloids ; bioactivities ; biomimetic synthesis