文章基本信息

标题：Reference Intervals for Non-Fasting CVD Lipids and Inflammation Markers in Pregnant Indigenous Australian Women
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作者：Tracy L. Schumacher ; Christopher Oldmeadow ; Don Clausen 等
期刊名称：Healthcare
电子版ISSN：2227-9032
出版年度：2017
卷号：5
期号：4
页码：72
DOI：10.3390/healthcare5040072
语种：English
出版社：MDPI Publishing
摘要：Indigenous Australians experience high rates of cardiovascular disease (CVD). The origins of CVD may commence during pregnancy, yet few serum reference values for CVD biomarkers exist specific to the pregnancy period. The Gomeroi gaaynggal research project is a program that undertakes research and provides some health services to pregnant Indigenous women. Three hundred and ninety-nine non-fasting samples provided by the study participants (206 pregnancies and 175 women) have been used to construct reference intervals for CVD biomarkers during this critical time. A pragmatic design was used, in that women were not excluded for the presence of chronic or acute health states. Percentile bands for non-linear relationships were constructed according to the methods of Wright and Royston (2008), using the xriml package in StataIC 13.1. Serum cholesterol, triglycerides, cystatin-C and alkaline phosphatase increased as gestational age progressed, with little change seen in high-sensitivity C-Reactive Protein and γ glutamyl transferase. Values provided in the reference intervals are consistent with findings from other research projects. These reference intervals will form a basis with which future CVD biomarkers for pregnant Indigenous Australian women can be compared.
关键词：cardiovascular; biomarkers; lipids; inflammation; pregnancy; gestation; Australian Aborigine; reference growth curves cardiovascular ; biomarkers ; lipids ; inflammation ; pregnancy ; gestation ; Australian Aborigine ; reference growth curves