文章基本信息

标题：Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer
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作者：Olivier Belzile ; Xianming Huang ; Jian Gong 等
期刊名称：ImmunoTargets and Therapy
电子版ISSN：2253-1556
出版年度：2018
卷号：7
页码：1-14
DOI：10.2147/ITT.S134834
语种：English
出版社：Dove Medical Press Ltd
摘要：Phosphatidylserine (PS) is a negatively charged phospholipid in all eukaryotic cells that is actively sequestered to the inner leaflet of the cell membrane. Exposure of PS on apoptotic cells is a normal physiological process that triggers their rapid removal by phagocytic engulfment under noninflammatory conditions via receptors primarily expressed on immune cells. PS is aberrantly exposed in the tumor microenvironment and contributes to the overall immunosuppressive signals that antagonize the development of local and systemic antitumor immune responses. PS-mediated immunosuppression in the tumor microenvironment is further exacerbated by chemotherapy and radiation treatments that result in increased levels of PS on dying cells and necrotic tissue. Antibodies targeting PS localize to tumors and block PS-mediated immunosuppression. Targeting exposed PS in the tumor microenvironment may be a novel approach to enhance immune responses to cancer.
关键词：immunosuppression; tumor microenvironment; immunotherapy; imaging; phosphatidylserine; bavituximab