文章基本信息

标题：Study on the Relationship between Expression of LGR5 and Clinicopathological Characteristics in Gastric Cancer Patients
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作者：Xiulian Xu ; Qijun Lv ; Ping Xie 等
期刊名称：Health
印刷版ISSN：1949-4998
电子版ISSN：1949-5005
出版年度：2018
卷号：10
期号：01
页码：159-169
DOI：10.4236/health.2018.101013
语种：English
出版社：Scientific Research Publishing
摘要：The aim of the study was to clarify the role of LGR5 in the process of formation and development of gastric cancer. The expression of LGR5 in gastric cancer and corresponding non-cancerous gastric tissues of 52 gastric cancer patients was assessed with the real-time fluorescence quantitative polymerase chain reaction (RT-PCR) and immunohistochemistry. We also analyzed the relationship between the expression level and clinicopathological characteristics. LGR5 gene and protein expression in gastric cancer tissues was in both cases significantly higher than in corresponding non-cancerous gastric tissues (both P 0.05, respectively). Furthermore, LGR5 gene expression was markedly higher in gastric cancer tissues of Helicobacter pylori (HP)-positive patients than negative ones (P < 0.05). The result of the study showed that LGR5 might play a significant role in the process of formation and development of gastric cancer as an oncogene. Its effect might be strengthened by HP infection.
关键词：LGR5;Clinicopathological Characteristics;Gastric Cancer;HP