摘要:Early prediction of diseases especially dengue fever in the case of Malaysia, is very crucial to enable health authorities to develop response strategies and context preventive intervention programs such as awareness campaigns for the high risk population before an outbreak occurs. Some of the deficiencies in dengue epidemiology are insufficient awareness on the parameter as well as the combination among them. Most of the studies on dengue prediction use standalone models which face problem of finding the appropriate parameter since they need to apply try and error approach. The aim of this paper is to conduct experiments for determining the best network structure that has effective variable and fitting parameters in predicting the spread of the dengue outbreak. Four model structures were designed in order to attain optimum prediction performance. The best model structure was selected as predicting model to solve the time series prediction of dengue. The result showed that neighboring location of dengue cases was very effective in predicting the dengue outbreak and it is proven that the hybrid Genetic Algorithm and Neural Network (GANN) model significantly outperforms standalone models namely regression and Neural Network (NN).