文章基本信息

标题：Platelet count and indoor cold exposure among elderly people: A cross-sectional analysis of the HEIJO-KYO study
本地全文：下载
作者：Keigo Saeki ; Kenji Obayashi ; Norio Kurumatani 等
期刊名称：Journal of Epidemiology
印刷版ISSN：0917-5040
电子版ISSN：1349-9092
出版年度：2017
卷号：27
期号：12
页码：562-567
DOI：10.1016/j.je.2016.12.018
语种：English
出版社：Japan Epidemiological Association
摘要：Background: Excess mortality from cardiovascular disease during cold seasons is a worldwide issue. Although some physiologic studies suggests that platelet activation via cold exposure may cause an increased incidence of cardiovascular disease in winter, the influence of indoor cold exposure in real-life situations on platelet (PLT) count remains unclear. Methods: A cross-sectional study was conducted among 1095 elderly individuals. After obtaining a venous sample in the morning, indoor temperature of participants' home was measured every 10 min for 48 h. The mean indoor temperature while the participants stayed at home was calculated. All measurement was conducted during cold seasons (October to April) from 2010 to 2014. Results: The mean age of the 1095 participants was 71.9 years. They spent 87.3% of the day at home (20 h 27 min). A 1 °C lower daytime indoor temperature was associated with a significant increase in PLT count of 1.47 × 10⁹/L (95% confidence interval, 0.39–2.56 × 10⁹/L). Compared with the warmest tertile group (20.1 [standard deviation {SD}, 0.09] °C), the coldest group (11.7 [SD, 0.12] °C) showed a 5.2% higher PLT count (238.84 [SD, 3.30] vs. 226.48 [SD, 3.32] × 10⁹/L; P = 0.01), even after adjusting for basic characteristics (age, gender, body weight, and smoking), antihypertensive medication, comorbidities (diabetes, estimated glomerular filtration rate), socioeconomic status (household income and education), day length, and outdoor temperature. Conclusions: We found a significant and independent association between lower indoor temperature and higher PLT count among elderly in winter.
关键词：Platelet count;Indoor temperature;Elderly