文章基本信息

标题：Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes
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作者：Barbara Ludwig ; Stefan Ludwig ; Anja Steffen 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2017
卷号：114
期号：44
页码：11745-11750
DOI：10.1073/pnas.1708420114
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.
关键词：diabetes ; porcine islets ; beta-cell replacement ; immune barrier