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  • 标题:Individual differences in associative memory among older adults explained by hippocampal subfield structure and function
  • 本地全文:下载
  • 作者:Valerie A. Carr ; Jeffrey D. Bernstein ; Serra E. Favila
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2017
  • 卷号:114
  • 期号:45
  • 页码:12075-12080
  • DOI:10.1073/pnas.1713308114
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Older adults experience impairments in episodic memory, ranging from mild to clinically significant. Given the critical role of the medial temporal lobe (MTL) in episodic memory, age-related changes in MTL structure and function may partially account for individual differences in memory. Using ultra–high-field 7T structural MRI and high-resolution 3T functional MRI (hr-fMRI), we evaluated MTL subfield thickness and function in older adults representing a spectrum of cognitive health. Participants performed an associative memory task during hr-fMRI in which they encoded and later retrieved face–name pairs. Motivated by prior research, we hypothesized that differences in performance would be explained by the following: ( i ) entorhinal cortex (ERC) and CA1 apical neuropil layer [CA1–stratum radiatum lacunosum moleculare (SRLM)] thickness, and ( ii ) activity in ERC and the dentate gyrus (DG)/CA3 region. Regression analyses revealed that this combination of factors significantly accounted for variability in memory performance. Among these metrics, CA1-SRLM thickness was positively associated with memory, whereas DG/CA3 retrieval activity was negatively associated with memory. Furthermore, including structural and functional metrics in the same model better accounted for performance than did single-modality models. These results advance the understanding of how independent but converging influences of both MTL subfield structure and function contribute to age-related memory impairment, complementing findings in the rodent and human postmortem literatures.
  • 关键词:episodic memory ; hippocampus ; aging ; mild cognitive impairment ; Alzheimer’s disease
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