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标题：Tissue distribution patterns of solubilized metals from internalized tungsten alloy in the F344 rat
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作者：Vernieda B. Vergara ; Christy A. Emond ; John F. Kalinich 等
期刊名称：AIMS Environmental Science
印刷版ISSN：2372-0344
电子版ISSN：2372-0352
出版年度：2016
卷号：3
期号：2
页码：290-304
DOI：10.3934/environsci.2016.2.290
摘要：Because of its unique physical and chemical properties, tungsten has been increasingly utilized in a variety of civilian and military applications. This expanded use also raises the risk of human exposure through internalization by various routes. In most cases the toxicological and carcinogenic properties of these tungsten-based compounds are not known nor are the dissolution biokinetics and ultimate fate of the associated metals. Using a laboratory rodent model system designed to assess the health effects of embedded metals, and a tungsten alloy comprised of tungsten (91.1%), nickel (6.0%), and cobalt (2.9%), we investigated the tissue distribution patterns of the metals over a six month period. Despite its perceived insolubility, tungsten rapidly solubilized from the implanted metal fragments, as did nickel and cobalt. All three metals distributed systemically over time with extremely elevated levels of all three metals found in kidney, liver, and spleen. Unexpectedly, tungsten was found to cross the blood-brain and blood-testis barriers and localize in those tissues. These results, along with recent reports suggesting that tungsten is a tumor promoter, raises serious concerns as to the long-term health effects of exposure to tungsten and tungsten-based compounds.
关键词：tungsten alloy (WA); tungsten (W); nickel (Ni); cobalt (Co); wound; contamination; rat; inductively coupled; plasma mass spectrometry (ICP; MS)