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标题：Association between serum vitamin Dand metabolic syndrome in middle-agedand older adults and role ofsupplementation therapy with vitamin D
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作者：Walter Verrusio ; Paola Andreozzi ; Alessia Renzi 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2017
卷号：53
期号：1
页码：54-59
DOI：10.4415/ANN_17_01_11
出版社：Editrice Kurtis Srl
摘要：Objectives. To evaluate i) the correlation between vitamin D (vit. D) serum concentrationsand metabolic syndrome (MetS); ii) the efficacy of 6 months supplementationtherapy with vit. D.Method. 200 patients were enrolled. Blood analyses and anthropometric measurementswere carried out. Patients with hypovitaminosis D received an oral supplement therapy.Results. 81% of the sample shows vit. D levels < 30 ng/mL. Rate of MetS was significantlyhigher in vit. D deficiency group than in vit D insufficiency (p = 0.009) and sufficiency(p = 0.002) groups. Vit. D shows a significant negative correlation with both waist circumference(WC) (ρ - 0.202 p = 0.004) and glycaemia values (FBG) (ρ -0.185 p = 0.009).After the supplementation therapy in a group of 60 subjects a significant increase in vit.D levels (p = 0.001) and a significant reduction in WC values (p = 0.001) were observed.Conclusions. MetS, WC and FBG appeared to be associated vit. D status and it is wellknownthat central obesity, with the inflammatory alterations thereto correlated thatdetermine insulin resistance, can be considered the “primum movens” for the developmentof MetS.
关键词：vitamin D; elderly; supplementation; metabolic syndrome; cardiovascular risk