文章基本信息

标题：Mechanisms of Anticonvulsant Action of Residual Aqueous Fraction (RAF) of the Ethanol Root Bark Extract of Carissa edulis
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作者：Jamilu Ya’u ; Abdullahi Hamza Yaro ; Aliyu Muhammad Musa 等
期刊名称：Journal of Natural Sciences Research
印刷版ISSN：2225-0921
电子版ISSN：2225-0921
出版年度：2014
卷号：4
期号：22
页码：43-48
语种：English
出版社：The International Institute for Science, Technology and Education (IISTE)
摘要：Preparations of Carissa edulis (Vahl) have been used in the Nigerian traditional medicine for the management of fever, sickle cell disease, epilepsy, pain cancer and inflammatory conditions for many years and their efficacy is widely acclaimed among the Hausa communities of Northern Nigeria. The possible mechanism(s) involved in the anticonvulsant action of residual aqueous fraction of ethanol root bark extract of Carissa edulis (RAF) were determined using flumazenil, naloxone, cyproheptadine, bisindolylmaleimide (BIM), ibuprofen and misoprostol. Flumazenil antagonized the anticonvulsant effect of both RAF and diazepam, while BIM promoted their anticonvulsant effect. However, naloxone and cyproheptadine did not affect the RAF anticonvulsant effect. Ketoprofen increased the RAF and valproate anticonvulsant activity while misoprostol did not alter their effects. The interaction studies revealed that GABAergic, glycine, serotonergic and opioid neurotransmission were found to be involved in the RAF anticonvulsant effects.
关键词：Anticonvulsant; Bisindolylmaleimide; Flumazenil; GABA; serotonergic; opioids