文章基本信息

标题：Ethanol-Induced Hepatic and Renal Histopathological Changes in BALB/c mice
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作者：Snur MA Hassan ; Azad K Saeed ; Adel Jabbar Hussein 等
期刊名称：Journal of Natural Sciences Research
印刷版ISSN：2225-0921
电子版ISSN：2225-0921
出版年度：2015
卷号：5
期号：10
页码：12-20
语种：English
出版社：The International Institute for Science, Technology and Education (IISTE)
摘要：This study was to investigate the histopathologic changes of different concentrations of ethanol on the mice liver and kidney. Forty albino mice of the Mus musculus species, BALB/c strain mice underwent this study and were divided into four groups; control, %20, %40 and %60 of ethanol administration groups. The mice of each group (%20, %40 and %60 of ethanol) were orally administered with 1ml of ethanol 4days/week for 3 weeks. Hematoxylin and eosin staining indicated development of mild to severe lesions in kidney and liver which included; In %20 of ethanol administration group there was mild lesion development; hydropic swelling in liver and swelling of kidney parenchyma while in %40 of ethanol administration group developed moderate changes; hydropic swelling of hepatocytes and kidney tubules with hyaline degeneration and in %60 of ethanol administration group produced severe lesion; focal macro and micro abscess in liver parenchyma and focal neutrophil infiltration within renal parenchyma and hyaline cast within renal tubules. Based on our study, it can be concluded that ethanol intoxication leads to a various disorders of the liver and kidney which arrange from mild to severe injury which was depended on the concentration of ethanol.
关键词：Ethanol; Mice; Kidney; Liver; H&E stain.