文章基本信息

标题：Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization
本地全文：下载
作者：Jad Maamary ; Taia T. Wang ; Gene S. Tan 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2017
卷号：114
期号：38
页码：10172-10177
DOI：10.1073/pnas.1707950114
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The main barrier to reduction of morbidity caused by influenza is the absence of a vaccine that elicits broad protection against different virus strains. Studies in preclinical models of influenza virus infections have shown that antibodies alone are sufficient to provide broad protection against divergent virus strains in vivo. Here, we address the challenge of identifying an immunogen that can elicit potent, broadly protective, antiinfluenza antibodies by demonstrating that immune complexes composed of sialylated antihemagglutinin antibodies and seasonal inactivated flu vaccine (TIV) can elicit broadly protective antihemagglutinin antibodies. Further, we found that an Fc-modified, bispecific monoclonal antibody against conserved epitopes of the hemagglutinin can be combined with TIV to elicit broad protection, thus setting the stage for a universal influenza virus vaccine.
关键词：TIV ; immune complex ; universal influenza vaccine ; CD23 ; sialylated Fc