文章基本信息

标题：Reactive oxygen species extend insect life span using components of the insulin-signaling pathway
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作者：Xiao-Shuai Zhang ; Tao Wang ; Xian-Wu Lin 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2017
卷号：114
期号：37
页码：E7832-E7840
DOI：10.1073/pnas.1711042114
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Reactive oxygen species (ROS) are well-known accelerants of aging, but, paradoxically, we show that physiological levels of ROS extend life span in pupae of the moth Helicoverpa armigera , resulting in the dormant state of diapause. This developmental switch appears to operate through a variant of the conventional insulin-signaling pathway, as evidenced by the facts that Akt, p-Akt, and PRMT1 are elevated by ROS, but not insulin, and that high levels of p-Akt fail to phosphorylate FoxO through PRMT1-mediated methylation. These results suggest a distinct signaling pathway culminating in the elevation of FoxO, which in turn promotes the extension of life span characteristic of diapause.
关键词：insulin signaling ; Akt ; PRMT1 ; insects ; diapause