文章基本信息

标题：Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran
其他标题：Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran
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作者：Molood FARROKHI ; Samaneh MOALLEMI ; Reza SHIRKOOHI 等
期刊名称：Iranian Journal of Public Health
印刷版ISSN：2251-6085
电子版ISSN：2251-6093
出版年度：2017
卷号：46
期号：9
页码：1256-1264
语种：English
出版社：Tehran University of Medical Sciences
摘要：AbstractBackground: This study aimed to determine drug resistance mutations in patients with virological failure and find correlation between HIV drug resistance test and viral load.Methods: Blood sample was collected from 51 patients who suspicious treatment failure in the center of Imam Khomeini Hospital, Tehran, Iran in 2015. Viral voluntary counseling and testing load test was done and the patients with viral load above 1000 copies choose for detection of drug resistance mutations by genotyping method (29 patients).Results: The majority of patients (82.75) harbored the HIV subtype CRF 35 A-D. The 86.2% patients compromised at least one resistance mutation. The analysis of reverse transcriptase showed M184V (68.9%), T215YISF (44.8%), K103N (27.6%) and the analysis results of protease revealed G73SC (13.8%) and I47VA (6.9%). Eventually, the significant correlation between viral load and drug resistance was found.Conclusion: The result of our research stress the significance of recognizing drug resistant on time that prohibits the accumulation of drug resistance mutation and circulates the resistance strain of HIV-1 virus and the importance of national study according to the reliable findings for treatment guidelines.
关键词：Treatment failure; Drug resistance; Phylogeny; HIV