文章基本信息

标题：1-Phenyl-2-(pyrrolidin-1-yl)pentan-1-one(α-PVP) の3種の類縁化合物のヒトにおける尿中代謝物及び代謝経路
本地全文：下载
作者：Hidenao Kakehashi ; Noriaki Shima ; Hiroe Kamata 等
期刊名称：日本法科学技術学会誌
印刷版ISSN：1880-1323
电子版ISSN：1881-4689
出版年度：2017
卷号：22
期号：2
页码：77-90
DOI：10.3408/jafst.735
出版社：Japanese Association of Forensic Science and Technology
摘要：Three analogues of 1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one (α-PVP), 1-(4-fluorophenyl)-2-(pyrolidin-1-yl)pentan-1-one (4F-α-PVP), 1-(4-methoxyphenyl)-2-(pyrrolidin-1-yl)pentan-1-one (4MeO-α-PVP) and 2-(pyrrolidin-1-yl)-1-(thiophen-2-yl)pentan-1-one (α-PVT), and their metabolites were determined in users' urine by liquid chromatography-tandem mass spectrometry using newly synthesized authentic standards. The identified metabolites indicated that metabolic pathways of three α-PVP analogues include the reduction of the carbonyl group to the corresponding alcohols and the oxidation of the pyrrolidine ring to the corresponding pyrrolidone, and 4MeO-α-PVP and α-PVT have additional metabolic pathways of the O -demethylation and the oxidation of thienyl group respectively. The quantitative analyses of the urinary metabolites suggested that the main metabolic pathways of these α-pyrrolidinophenones (PPs) derivatives could vary largely depending on the aromatic rings or substituent groups on the aromatic ring of PPs.
关键词：Cathinone ; Human urine ; Metabolism ; LC-MS/MS ; α-pyrrolidinophenone