首页    期刊浏览 2024年12月11日 星期三
登录注册

文章基本信息

  • 标题:Troponin I is present in human cartilage and inhibits angiogenesis
  • 本地全文:下载
  • 作者:Marsha A. Moses ; Dmitri Wiederschain ; Inmin Wu
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1999
  • 卷号:96
  • 期号:6
  • 页码:2645-2650
  • DOI:10.1073/pnas.96.6.2645
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Cartilage is an avascular and relatively tumor-resistant tissue. Work from a number of laboratories, including our own, has demonstrated that cartilage is an enriched source of endogenous inhibitors of angiogenesis. In the course of a study designed to identify novel cartilage-derived inhibitors of new capillary growth, we have purified an inhibitory protein that was identified by peptide microsequencing and protein database analysis as troponin I (TnI). TnI is a subunit of the troponin complex (troponin-C and troponin-T being the other two), which, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction; independently, TnI is capable of inhibiting actomyosin ATPase. Because troponin has never previously been reported to be present in cartilage, we have cloned and expressed the cDNA of human cartilage TnI, purified this protein to apparent homogeneity, and demonstrated that it is a potent and specific inhibitor of angiogenesis in vivo and in vitro, as well as of tumor metastasis in vivo.
  • 关键词:endothelial cells ; neovascularization ; metastasis inhibitor
国家哲学社会科学文献中心版权所有