文章基本信息

标题：Interferon γ expressed by a recombinant respiratory syncytial virus attenuates virus replication in mice without compromising immunogenicity
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作者：Alexander Bukreyev ; Stephen S. Whitehead ; Natalya Bukreyeva 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：5
页码：2367-2372
DOI：10.1073/pnas.96.5.2367
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Interferon {gamma} (IFN-{gamma}) has pleiotropic biological effects, including intrinsic antiviral activity as well as stimulation and regulation of immune responses. An infectious recombinant human respiratory syncytial virus (rRSV/mIFN-{gamma}) was constructed that encodes murine (m) IFN-{gamma} as a separate gene inserted into the G-F intergenic region. Cultured cells infected with rRSV/mIFN-{gamma} secreted 22 {micro}g mIFN-{gamma} per 106 cells. The replication of rRSV/mIFN-{gamma
关键词：vaccine ; immunization ; paramyxovirus ; cytokine