文章基本信息

标题：DNA transport by a micromachined Brownian ratchet device
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作者：Joel S. Bader ; Richard W. Hammond ; Steven A. Henck 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：23
页码：13165-13169
DOI：10.1073/pnas.96.23.13165
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have micromachined a silicon-chip device that transports DNA with a Brownian ratchet that rectifies the Brownian motion of microscopic particles. Transport properties for a DNA 50-mer agree with theoretical predictions, and the DNA diffusion constant agrees with previous experiments. This type of micromachine could provide a generic pump or separation component for DNA or other charged species as part of a microscale lab-on-a-chip. A device with reduced feature size could produce a size-based separation of DNA molecules, with applications including the detection of single-nucleotide polymorphisms.