文章基本信息

标题：Pearling in cells: A clue to understanding cell shape
本地全文：下载
作者：Roy Bar-Ziv ; Tsvi Tlusty ; Elisha Moses 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：18
页码：10140-10145
DOI：10.1073/pnas.96.18.10140
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Gradual disruption of the actin cytoskeleton induces a series of structural shape changes in cells leading to a transformation of cylindrical cell extensions into a periodic chain of "pearls." Quantitative measurements of the pearling instability give a square-root behavior for the wavelength as a function of drug concentration. We present a theory that explains these observations in terms of the interplay between rigidity of the submembranous actin shell and tension that is induced by boundary conditions set by adhesion points. The theory allows estimation of the rigidity and thickness of this supporting shell. The same theoretical considerations explain the shape of nonadherent edges in the general case of untreated cells.