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  • 标题:Intracellular σ1 receptor modulates phospholipase C and protein kinase C activities in the brainstem
  • 本地全文:下载
  • 作者:M. P. Morin-Surun ; T. Collin ; M. Denavit-Saubié
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1999
  • 卷号:96
  • 期号:14
  • 页码:8196-8199
  • DOI:10.1073/pnas.96.14.8196
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Most physiological effects of {sigma}1 receptor ligands are sensitive to pertussis toxin, suggesting a coupling with cell membrane-bound G proteins. However, the cloning of the {sigma}1 receptor has allowed the identification of an intracellular protein anchored on the endoplasmic reticulum. Here, we show, using the isolated adult guinea pig brainstem preparation, that activation of the {sigma}1 receptor results in its translocation from the cytosol to the vicinity of the cell membrane and induces a robust and rapid decrease in hypoglossal activity, which is mediated by phospholipase C. The subsequent activation of protein kinase C {beta}1 and {beta}2 isoforms and the phosphorylation of a protein of the same molecular weight as the cloned {sigma}1 receptor lead to a desensitization of the {sigma}1 motor response. Our results indicate that the intracellular {sigma}1 receptor regulates several components implicated in plasma membrane-bound signal transduction. This might be an example of a mechanism by which an intracellular receptor modulates metabotropic responses.
  • 关键词:respiratory activity ; motor control
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