文章基本信息

标题：Comparison of the intracellular signaling responses by three chimeric fibroblast growth factor receptors in PC12 cells
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作者：Simona Raffioni ; Didier Thomas ; Erik D. Foehr 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：13
页码：7178-7183
DOI：10.1073/pnas.96.13.7178
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Stably transfected PC12 cell lines expressing similar amounts of chimeric receptors composed of the extracellular domain of the human platelet-derived growth factor (PDGF){beta} receptor and the transmembrane and intracellular domains of the fibroblast growth factor receptors (FGFRs) 1, 3, and 4 undergo ligand-induced differentiation. The FGFR1 chimera (PFR1) is the most potent of the three, and PFR4 requires more frequent (every 24 hr) addition of ligand to maintain the response. Both PFR1 and -3 also show significant ligand-independent autophosphorylation but PFR4 does not. All of the chimeras activated phospholipase C{gamma