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标题：Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB
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作者：Veronika Groh ; Rebecca Rhinehart ; Heather Secrist 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1999
卷号：96
期号：12
页码：6879-6884
DOI：10.1073/pnas.96.12.6879
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Human MHC class I-related molecules, MICA and MICB, are stress-induced antigens that are recognized by a subset of {gamma}{delta} T cells expressing the variable region V{delta}1. This functional association has been found to be limited to intestinal epithelium, where these T cells are prevalent and where MICA and, presumably, MICB are mainly expressed. However, increased frequencies of V{delta}1 {gamma}{delta} T cells have been observed in various epithelial tumors; moreover, MICA/B are expressed on diverse cultured epithelial tumor cells. With freshly isolated tumor specimens, expression of MICA/B was documented in many, but not all, carcinomas of the lung, breast, kidney, ovary, prostate, and colon. In tumors that were positive for MICA/B, the frequencies of V{delta}1 {gamma}{delta} T cells were significantly higher than in those that were negative. V{delta}1 {gamma}{delta} T cell lines and clones derived from different tumors recognized MICA/B on autologous and heterologous tumor cells. In accord with previous evidence, no constraints were observed in these interactions, such as those imposed by specific peptide ligands. Thus, MICA/B are tumor-associated antigens that can be recognized, in an apparently unconditional manner, by a subset of tumor-infiltrating {gamma}{delta} T cells. These results raise the possibility that an induced expression of MICA/B, by conditions that may be related to tumor homeostasis and growth, could play a role in immune responses against tumors.