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标题：Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS
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作者：Daniel Zagury ; Abderrahim Lachgar ; Vida Chams 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：7
页码：3851-3856
DOI：10.1073/pnas.95.7.3851
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：HIV type 1 (HIV-1) not only directly kills infected CD4+ T cells but also induces immunosuppression of uninfected T cells. Two immunosuppressive proteins, interferon (IFN) and extracellular Tat, mediate this process because specific antibodies against these proteins prevent generation of suppressor cells in HIV-1-infected peripheral blood mononuclear cell cultures. Furthermore, the production of C-C chemokines in response to immune cell activation, initially enhanced by IFN and Tat, ultimately is inhibited by these proteins in parallel with their induction of immunosuppression. The clinical corollary is the immunosuppression of uninfected T cells and the decline in C-C chemokine release found at advanced stages of HIV-1 infection paralleling rising levels of IFN and extracellular Tat. We, therefore, suggest that IFN and Tat may be critical targets for anti-AIDS strategies.