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标题：Natural killer activating receptors trigger interferon γ secretion from T cells and natural killer cells
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作者：Ofer Mandelboim ; Sally Kent ; Daniel M. Davis 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：7
页码：3798-3803
DOI：10.1073/pnas.95.7.3798
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Proliferation of human CD4+ {beta} T cells expressing a natural killer cell activating receptor (NKAR) has been shown to be enhanced, particularly in response to low doses of antigen, if the target cells present appropriate human class I major histocompatibility complex (MHC) molecules. Here, we show that NKAR also enhance proliferation and killing of target cells by subsets of CD8+ {beta} and CD8+ {gamma}{delta} T cells, as well as by NK cells. Strikingly, interferon {gamma} secretion from all of these types of lymphocytes was markedly increased by interaction of the NKAR with their MHC class I ligands, independently of enhancement of proliferation. Thus, the recognition of class I MHC molecules by NKAR on both T cells and NK cells may provide a regulatory mechanism that affects immune responses through the secretion of interferon {gamma} and possibly other cytokines. It represents a signal for cytokine secretion alternative and/or augmentative to that through the T cell receptor.