文章基本信息

标题：Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
本地全文：下载
作者：Hiroyasu Nakano ; Masahisa Shindo ; Sachiko Sakon 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：7
页码：3537-3542
DOI：10.1073/pnas.95.7.3537
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：NF-{kappa}B is activated by various stimuli including inflammatory cytokines and stresses. A key step in the activation of NF-{kappa}B is the phosphorylation of its inhibitors, I{kappa}Bs, by an I{kappa}B kinase (IKK) complex. Recently, two closely related kinases, designated IKK and IKK{beta