文章基本信息

标题：Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene
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作者：Andreas Zimmer ; Anne M. Zimmer ; Judith Baffi 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：5
页码：2630-2635
DOI：10.1073/pnas.95.5.2630
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The tachykinin neuropeptides, substance P and substance K, are produced in nociceptive primary sensory neurons and in many brain regions involved in pain signaling. However, the precise role and importance of these neuropeptides in pain responses has been debated. We now show that mice that cannot produce these peptides display no significant pain responses following formalin injection and have an increased pain threshold in the hotplate test. On the other hand, the mutant mice react normally in the tail flick assay and acetic acid-induced writhing tests. These results demonstrate that substance P and/or substance K have essential functions in specific responses to pain.