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  • 标题:Targeted deletion of Smad4 shows it is required for transforming growth factor β and activin signaling in colorectal cancer cells
  • 本地全文:下载
  • 作者:Shibin Zhou ; Phillip Buckhaults ; Leigh Zawel
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1998
  • 卷号:95
  • 期号:5
  • 页码:2412-2416
  • DOI:10.1073/pnas.95.5.2412
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Smad4 (DPC4) is a candidate tumor suppressor gene that has been hypothesized to be critical for transmitting signals from transforming growth factor (TGF) {beta} and related ligands. To directly test this hypothesis, the Smad4 gene was deleted through homologous recombination in human colorectal cancer cells. This deletion abrogated signaling from TGF-{beta
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