文章基本信息

标题：Impaired metabolic modulation of α-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle
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作者：Gail D. Thomas ; Mikael Sander ; Kim S. Lau 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：25
页码：15090-15095
DOI：10.1073/pnas.95.25.15090
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The neuronal isoform of nitric oxide synthase (nNOS) is highly expressed in mammalian skeletal muscle, but its functional role has not been defined. NO has been implicated in the local metabolic regulation of blood flow in contracting skeletal muscle in part by antagonizing sympathetic vasoconstriction. We therefore hypothesized that nNOS in skeletal muscle is the source of the NO mediating the inhibition of sympathetic vasoconstriction in contracting muscle. In the mdx mouse, a model of Duchenne muscular dystrophy in which dystrophin deficiency results in greatly reduced expression of nNOS in skeletal muscle, we found that the normal ability of skeletal muscle contraction to attenuate -adrenergic vasoconstriction is defective. Similar results were obtained in mutant mice that lack the gene encoding nNOS. Together these data suggest a specific role for nNOS in the local metabolic inhibition of -adrenergic vasoconstriction in active skeletal muscle.