文章基本信息

标题：Pontin52, an interaction partner of β-catenin, binds to the TATA box binding protein
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作者：Andreas Bauer ; Otmar Huber ; Rolf Kemler 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1998
卷号：95
期号：25
页码：14787-14792
DOI：10.1073/pnas.95.25.14787
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：{beta}-catenin, the vertebrate homolog of the Drosophila Armadillo protein, has been shown to have dual cellular functions, as a component of both the cadherin-catenin cell adhesion complex and the Wnt signaling pathway. At Wnt signaling, {beta}-catenin becomes stabilized in the cytoplasm and subsequently available for interaction with transcription factors of the lymphocyte enhancer factor-1/T-cell factor family, resulting in a nuclear localization of {beta}-catenin. Although {beta}-catenin does not bind DNA directly, its carboxyl- and amino-terminal regions exhibit a transactivating activity still not well understood molecularly. Here we report the identification of an interaction partner of {beta}-catenin, a nuclear protein designated Pontin52. Pontin52 binds {beta}-catenin in the region of Armadillo repeats 2-5 and, more importantly, also binds the TATA box binding protein. We provide evidence for an in vivo multiprotein complex composed of Pontin52, {beta}-catenin, and lymphocyte enhancer factor-1/T-cell factor. Our results suggest involvement of Pontin52 in the nuclear function of {beta}-catenin.
关键词：transcription regulation